Effects of aging on the evolution of Apical Periodontitis lesions in rats

This study aimed to evaluate the effects of aging on evolution Apical Periodontitis (AP) lesions in rats. Elderly males (study group, n = 12) and young (control Wistar rats were used. When group 24 months old control 3 old, AP induced by creating pulp exposure mandibular left first molars. After 21 40 days, animals euthanized mandibles removed. The hemi- radiographed mesial roots molars measured using ImageJ software (National Institute Mental Health, Bethesda, USA). significantly larger (E) (p 0.0006) compared Control (C) (E 21: 218.8 ± 72.96, C 94.77 9.44, E 40: 237.8 57.20, 85.23 6.63). elderly groups than younger animals. These findings suggest that bone immunological changes caused can influence progression lesions.